protein
30
Proteins validated
5
Binders
AMBP regulates protein stability and immune response. Altered AMBP levels are associated with kidney dysfunction and inflammatory diseases.
16
4
DER21 regulates cellular stress responses and protein degradation. Altered levels are associated with neurodegenerative diseases and impaired cell function.
20
DERF7 is a transcription factor involved in regulating immune responses. Alterations in its expression are associated with immune system dysregulation and related diseases.
833
134
Epidermal Growth Factor Receptor (EGFR) regulates cell growth and differentiation. Alterations in its activity are linked with cancer progression and treatment resistance.
24
6
Receptor that binds to the Fc region of IgG antibodies and albumin, protecting them from degradation and extending their half-life. Dysregulation of FcRn can affect antibody clearance and is linked with autoimmune and inflammatory diseases.
7
FGF R1 regulates cell growth and development by mediating fibroblast growth factor signals. Alterations in its activity are linked with developmental disorders and cancer.
0
GM2A assists in the breakdown of specific lipids in the lysosome. Changes in its activity are linked with lipid storage disorders like Tay-Sachs disease.
2
Histamine N-methyltransferase (HNMT) regulates histamine levels by facilitating its breakdown. Altered activity of HNMT can be associated with allergic reactions and other histamine-mediated disorders.
IDI2 is involved in the synthesis of isoprenoids, crucial for cellular functions. Altered IDI2 activity can impact cholesterol levels and cell membrane integrity.
8
IFNAR2 is a receptor that mediates the effects of type I interferons. Altered IFNAR2 signaling can influence immune responses and is linked with autoimmune diseases and viral infections.
97
62
IL-7Ra is a receptor critical for the development and homeostasis of immune cells. Altered levels of IL-7Ra are associated with immune deficiencies and autoimmune disorders.
35
21
The insulin receptor controls how cells take up glucose. Changes in its signaling contribute to poor blood-sugar control and diabetes.
27
12
MDM2 regulates the p53 tumor suppressor, controlling cell cycle and apoptosis. Altered MDM2 activity is linked with cancer progression due to disrupted p53 regulation.
15
MZB1 regulates the proper folding and assembly of immunoglobulins in plasma cells. Variations in its expression are associated with immune disorders and lymphoproliferative diseases.
869
Nipah Virus Glycoprotein G mediates viral attachment to host cells. Changes in its expression or function can influence viral spread and disease severity.
ORM2, or orosomucoid 2, modulates inflammation and immune responses. Altered ORM2 levels are linked with inflammatory diseases and liver dysfunction.
18
PDGFR Beta regulates cell growth and development by responding to platelet-derived growth factors. Altered PDGFR Beta activity is linked with various cancers and fibrotic diseases.
75
39
PD-L1 (Programmed Death-Ligand 1) modulates immune responses by interacting with PD-1 on T cells. Altered PD-L1 levels are associated with immune evasion in cancers.
PHYH is involved in the breakdown of phytanic acid, a type of fatty acid. Disruption in PHYH activity can lead to an accumulation of phytanic acid, which is associated with Refsum disease and neurological symptoms.
10
Phosphomevalonate kinase (PMVK) is involved in cholesterol biosynthesis. Altered PMVK activity can impact cholesterol levels, influencing cardiovascular health.
Riboflavin kinase (RFK) catalyzes the phosphorylation of riboflavin to form flavin mononucleotide (FMN). Changes in RFK activity can affect cellular energy production and are linked with metabolic disorders.