Tested
Binders
An enzyme that switches off a signal involved in tissue repair. It grows more active with age, and blocking it rebuilds muscle and cartilage in mice.
One protein cut into two unrelated ones: an antioxidant used as a marker of kidney damage, and a blocker of protein-cutting enzymes.
BBF-14
BHRF1
The mouse counterpart of CD16a, used to test antibody-triggered cell killing in mice. Antibodies against the human version rarely bind it.
The docking site on immune cells that antibodies use to trigger the killing of a target cell. No approved drug binds it directly.
A house dust mite allergen. Between a third and a half of people allergic to dust mites make antibodies against it.
A house dust mite allergen that about half of dust mite allergic people react to, and one that provokes a strong T-cell response.
A growth signal receptor, mutated in many lung cancers and overproduced in brain tumours, and a target of both antibody and small-molecule drugs.
The receptor that rescues antibodies from being broken down, setting how long they last in the body. Drugs blocking it treat autoimmune disease.
A growth signal receptor present in extra copies in some lung and breast cancers, where it helps tumours resist hormone therapy.
A helper protein that hands a fatty molecule to the enzyme that breaks it down. Without it that fat builds up, causing a rare disease of infancy.
The enzyme that clears histamine from the brain. Children who inherit two broken copies have intellectual disability.
Calmodulin without calcium bound, its binding pockets closed. Even in this state it still holds on to certain partner proteins.
Calmodulin with calcium bound, which opens a pocket at each end and lets it grip more than 300 different partner proteins.
A marker on the surface of B cells, and the target of rituximab and several newer antibodies used against lymphoma and multiple sclerosis.
The most common protein in blood. It ferries fats, hormones, metals and many drugs, and survives about 19 days in circulation.
Human TrkA / NTRK1 (33-417) Protein
Human VEGF165
A near-copy of another enzyme in the cholesterol-building pathway, found mostly in muscle. No disease has been linked to it.
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