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NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, an aging-linked enzyme. Inhibiting 15-PGDH rejuvenates aged muscle stem cells, restores neuromuscular junctions, and repairs joint cartilage in preclinical models.

AMBP regulates protein stability and immune response. Altered AMBP levels are associated with kidney dysfunction and inflammatory diseases.

Mouse Fc gamma RIV (CD16-2), a receptor involved in antibody-dependent cellular cytotoxicity (ADCC).

Human Fc gamma RIIIA (CD16a), a receptor involved in antibody-dependent cellular cytotoxicity (ADCC).

DER21 regulates cellular stress responses and protein degradation. Altered levels are associated with neurodegenerative diseases and impaired cell function.

DERF7 is a transcription factor involved in regulating immune responses. Alterations in its expression are associated with immune system dysregulation and related diseases.

Epidermal Growth Factor Receptor (EGFR) regulates cell growth and differentiation. Alterations in its activity are linked with cancer progression and treatment resistance.

Receptor that binds to the Fc region of IgG antibodies and albumin, protecting them from degradation and extending their half-life. Dysregulation of FcRn can affect antibody clearance and is linked with autoimmune and inflammatory diseases.

FGF R1 regulates cell growth and development by mediating fibroblast growth factor signals. Alterations in its activity are linked with developmental disorders and cancer.

GM2A assists in the breakdown of specific lipids in the lysosome. Changes in its activity are linked with lipid storage disorders like Tay-Sachs disease.

Histamine N-methyltransferase (HNMT) regulates histamine levels by facilitating its breakdown. Altered activity of HNMT can be associated with allergic reactions and other histamine-mediated disorders.

Human CD20

Human Serum Albumin

IDI2 is involved in the synthesis of isoprenoids, crucial for cellular functions. Altered IDI2 activity can impact cholesterol levels and cell membrane integrity.

IFNAR2 is a receptor that mediates the effects of type I interferons. Altered IFNAR2 signaling can influence immune responses and is linked with autoimmune diseases and viral infections.

IL-7Ra is a receptor critical for the development and homeostasis of immune cells. Altered levels of IL-7Ra are associated with immune deficiencies and autoimmune disorders.

The insulin receptor controls how cells take up glucose. Changes in its signaling contribute to poor blood-sugar control and diabetes.

Maltose Binding Protein (MBP) from E. coli, a commonly used model antigen for binder development and VHH screening.

MDM2 regulates the p53 tumor suppressor, controlling cell cycle and apoptosis. Altered MDM2 activity is linked with cancer progression due to disrupted p53 regulation.

Myostatin (GDF-8) is a TGF-beta superfamily member that negatively regulates skeletal muscle growth. Inhibiting myostatin preserves lean muscle mass during GLP-1 therapy-induced weight loss.

MZB1 regulates the proper folding and assembly of immunoglobulins in plasma cells. Variations in its expression are associated with immune disorders and lymphoproliferative diseases.