Nipah Virus Glycoprotein G Target

Nipah virus glycoprotein G is the protein on the virus surface that grabs onto host cells. Four copies assemble into a spike: a stalk supporting a broad, propeller-shaped head. The head binds two human proteins, ephrin-B2 and ephrin-B3, found on nerve and blood vessel cells, and once attached it triggers a second viral protein, F, to fuse the virus and cell membranes. G does the attaching; F does the fusing. Nipah is on the WHO's priority pathogen list. It kills 40 to 75 percent of the people it infects, and there is no approved vaccine or treatment. It first appeared among Malaysian pig farmers in 1998 and now spills over from fruit bats almost every year in Bangladesh and repeatedly in Kerala, India, with person-to-person transmission documented. The leading countermeasure, an antibody called m102.4, finished a small safety trial in 2016 and has been given to about sixteen people after known exposure, all but one of them exposed to the related Hendra virus in Australia. It is not approved anywhere.

Nipah Virus Glycoprotein G

Description

Proteins targeting Nipah Virus Glycoprotein G (3852)

Proteins targeting Nipah Virus Glycoprotein G (…)

Proteins targeting Nipah Virus Glycoprotein G (3852)