GEM x Adaptyv Competition results are now available →

+2500 validated proteins

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Ended · Results available

GEM x Adaptyv: RBX1 Binder Design Competition

RBX1

300 proteins validated

Design protein binders targeting RBX1, a cancer-relevant E3 ubiquitin ligase component. Co-organized with the GEM Workshop at ICLR 2026.

GEM Workshop,

Adaptyv Bio

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Featured Proteins

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MIOTMassachusetts Institute of Technology

id: noble-bat-topaz

Binder

Nanobody

BoltzGen

Target

IL-7Ra

Binding

Strong

1.4e-9 M

True

12.5 kDa

119

id: lunar-zebra-topaz

Binder

scFv

Target

EGFR

Binding

Strong

1.9e-9 M

True

25.9 kDa

241

id: brisk-boar-cloud

Binder

Other

EvoDiff

Target

MDM2

Binding

Strong

1.7e-7 M

True

12.1 kDa

102

id: golden-cobra-iron

Binder

Other

BindCraft

Target

IFNAR2

Binding

Strong

5.7e-8 M

Expressed

True

Mol. Weight

11.1 kDa

AA Length

Featured Collections

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GEM x Adaptyv: RBX1 Binder Design Competition - Results

Adaptyv Bio • 18 days ago

Binding data

322 proteins

1 target

Results from the GEM x Adaptyv RBX1 Binder Design Competition.

+317

Nipah Competition Results

Adaptyv Bio • 3 months ago

Binding data

1201 proteins

2 targets

Experimental validation results for 1,196 protein designs targeting the deadly Nipah virus, yielding 111 binders (28 single-digit nM) with associated developability metrics.

+1196

BoltzGen Release

Massachusetts Institute of Technology • 6 months ago

Binding data

422 proteins

14 targets

To validate BoltzGen in its initial preprint release, 422 designed proteins were experimentally tested against 14 distinct targets.

+417

Popular Design Methods

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BoltzGen

All-atom diffusion-based generative model developed for de novo design of protein and peptide binders across a wide array of target types

1777 proteins generated

557 proteins tested

RFdiffusion

A flexible de novo binder design workflow using RFdiffusion for backbone generation

1564 proteins generated

136 proteins tested

BindCraft

Protein binder design pipeline that can be used to design miniprotein and peptide binders

594 proteins generated

171 proteins tested

Popular Targets

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Nipah Virus Glycoprotein G

protein

1201

Proteins validated

116

Binders

Nipah Virus Glycoprotein G mediates viral attachment to host cells. Changes in its expression or function can influence viral spread and disease severity.

EGFR

protein

826

Proteins validated

134

Binders

Epidermal Growth Factor Receptor (EGFR) regulates cell growth and differentiation. Alterations in its activity are linked with cancer progression and treatment resistance.

RBX1

protein

321

Proteins validated

Binders

RING Box Protein 1, a 108-amino acid component of the Cullin-RING E3 ubiquitin ligase (CRL) complex. CRLs control degradation of roughly 20% of all cellular proteins.

PD-L1

protein

110

Proteins validated

Binders

PD-L1 (Programmed Death-Ligand 1) modulates immune responses by interacting with PD-1 on T cells. Altered PD-L1 levels are associated with immune evasion in cancers.