The home of protein design data

Results from the GEM x Adaptyv RBX1 Binder Design Competition.

Experimental validation results for 1,196 protein designs targeting the deadly Nipah virus, yielding 111 binders (28 single-digit nM) with associated developability metrics.

To validate BoltzGen in its initial preprint release, 422 designed proteins were experimentally tested against 14 distinct targets.

The protein Nipah virus uses to latch onto human cells. The disease kills 40 to 75 percent of those infected and has no approved treatment.

A growth signal receptor, mutated in many lung cancers and overproduced in brain tumours, and a target of both antibody and small-molecule drugs.

The shared working part of a large family of enzymes that tag proteins for destruction, accounting for about a fifth of what a cell deliberately destroys.

An enzyme that switches off a signal involved in tissue repair. It grows more active with age, and blocking it rebuilds muscle and cartilage in mice.