Explore Proteins

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Affibody

DARPin

Fab

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Other

Peptide

scFv

Vnar

Small Protein

Target

EGFR

IFNAR2

spCas9

DER21

IL-7Ra

PD-L1

DERF7

MDM2

FGF R1

Nipah Virus Glycoprotein G

Insulin Receptor

PHYH

AMBP

GM2A

TNF-α

HNMT

ORM2

MZB1/PERP1

PDGFR Beta

IDI2

PMVK

RFK

FcRn

Human Serum Albumin

15-PGDH

TREM2

RBX1

Myostatin (GDF-8)

CD16a (Human Fc gamma R3A)

Maltose Binding Protein (MBP)

Human Calmodulin 1/CALM1 (apo, +EGTA)

Human Calmodulin 1/CALM1 (holo, +CaCl2)

Human VEGF110

SARS-CoV-2 RBD

Cn2

Ts1

AaH II

AaH I

LqhIII

CD16-2 (Mouse Fc gamma R4)

Binding Strength

Strong

Medium

Weak

None

Design Method

PPIFlow

BindCraft

BLOSUM62

Foundry

BoltzGen

ProtRL

ProTrek

DSM Synteract

co-TIMED

Mosaic

EvoDiff

Pro-1

PXDesign

Llama 3.1 405B

RFpeptides

AntiBERTy

RFdiffusion

ESM2 Optimization

Expression

Expressed

Not Expressed

De Novo

Not De Novo

Architecture

2 Layer Sandwich

3 Layer Aba Sandwich

3 Layer Bab Sandwich

3 Layer Bba Sandwich

3 Layer Sandwich

3 Solenoid

4 Layer Sandwich

4 Propeller

5 Propeller

6 Propeller

7 Propeller

8 Propeller

Alpha Alpha Barrel

Alpha Beta Barrel

Alpha Beta Complex

Alpha Beta Horseshoe

Alpha Horseshoe

Alpha Solenoid

Beta Barrel

Beta Complex

Box

Distorted Sandwich

Helix Non Globular

Irregular

Orthogonal Bundle

Other Non Globular

Ribbon

Roll

Sandwich

Shell

Single Sheet

Super Roll

Trefoil

Up Down Bundle

Classification

Alpha Beta

Few Secondary Structures

Mainly Alpha

Mainly Beta

Explore Proteins (4280)

TableGrid

GDGoogle DeepMind

id: swift-kiwi-birch

Binder

Miniprotein

AlphaProteo (parent sequence)

Target

PD-L1

Binding

Strong

7.7e-11 M

True

13.6 kDa

120

id: frozen-jaguar-moss

Binder

Miniprotein

AlphaProteo (parent sequence)

Target

Human VEGF110

Binding

Strong

9.1e-11 M

True

13.6 kDa

128

id: swift-lynx-vine

Binder

Miniprotein

Multiple (3)

Strong (2)

85.21

True

11.9 kDa

104

id: shy-goat-plume

Binder

Miniprotein

AlphaProteo (parent sequence)

Target

Human VEGF110

Binding

Strong

1.5e-10 M

True

12.9 kDa

127

id: pale-panda-maple

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

PD-L1

Binding

Strong

1.9e-10 M

True

13.6 kDa

120

id: amber-lynx-quartz

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN (no watermark)

Target

Human VEGF110

Binding

Strong

2.0e-10 M

True

10.5 kDa

id: young-shark-opal

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

Human VEGF110

Binding

Strong

2.3e-10 M

True

13.5 kDa

125

id: deep-gecko-maple

Binder

Other

Target

TREM2

Binding

Strong

2.3e-10 M

True

17.3 kDa

160

id: frozen-falcon-wave

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

PD-L1

Binding

Strong

2.5e-10 M

True

13.5 kDa

120

id: azure-tiger-moss

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

PD-L1

Binding

Strong

2.8e-10 M

True

13.7 kDa

120

id: calm-bison-clay

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

Human VEGF110

Binding

Strong

2.9e-10 M

True

10.6 kDa

id: hollow-bear-willow

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

PD-L1

Binding

Strong

3.6e-10 M

True

13.3 kDa

113

id: scarlet-seal-granite

Binder

scFv

Target

EGFR

Binding

Strong

3.7e-10 M

True

25.8 kDa

241

id: scarlet-raven-maple

Binder

Other

Multiple (2)

Strong (6)

83.70

True

15.7 kDa

137

id: azure-falcon-ivy

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Target

PD-L1

Binding

Strong

4.0e-10 M

True

13.3 kDa

120

id: lunar-bear-dust

Binder

scFv

Target

EGFR

Binding

Strong

4.0e-10 M

True

25.7 kDa

241

id: strong-quail-topaz

Binder

scFv

Target

EGFR

Binding

Strong

4.3e-10 M

True

25.8 kDa

241

id: azure-moth-vine

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN (no watermark)

Target

Human VEGF110

Binding

Strong

4.5e-10 M

True

10.6 kDa

id: lunar-mole-fern

Binder

Other

Multiple (2)

Strong (6)

83.70

True

15.6 kDa

137

id: pale-dove-moss

Binder

Miniprotein

AlphaProteo (parent sequence)

Target

Human VEGF110

Binding

Strong

5.4e-10 M

True

14.2 kDa

133

id: gentle-moth-leaf

Binder

Miniprotein

AlphaProteo backbone + ProteinMPNN (no watermark)

Target

Human VEGF110

Binding

Strong

5.7e-10 M

Expressed

True

Mol. Weight

10.4 kDa

AA Length