ORM2

ORM2, a member of the acute phase proteins, predominantly acts in the liver and circulates in the plasma. It plays a critical role in regulating the immune system's response to tissue damage or infection by modulating inflammation. ORM2 achieves this by binding to various cytokines and influencing their activity, thereby impacting the overall inflammatory response. Abnormal levels of ORM2, whether increased or decreased, can disrupt this regulatory balance, contributing to conditions such as chronic inflammation or liver disease. Mechanisms like gene overexpression, altered degradation, and changes in secretion rates can lead to these imbalances. Researchers and clinicians often measure ORM2 levels to assess the inflammatory state or liver function in patients. Techniques such as enzyme-linked immunosorbent assays (ELISAs) or mass spectrometry are commonly used to quantify ORM2 in blood samples. By understanding ORM2 dynamics, scientists can better elucidate its role in disease processes and potentially identify it as a therapeutic target. Modulating ORM2 levels or activity could offer new avenues for treating inflammation-related diseases, making it a protein of significant interest in both clinical diagnostics and therapeutic development.