DERF7

Der p 7 is produced by Dermatophagoides pteronyssinus and resembles bacterial lipid-binding proteins. It travels with dust particles, staying stable enough to reach the airways. Sensitized individuals often carry high-titer IgE against Der p 7, linking it to persistent rhinitis and asthma. The allergen can activate basophils and epithelial sensors, reinforcing type 2 inflammation alongside other mite components. Binders that neutralize Der p 7 or alter its lipid cargo let formulators dial down the allergen's potency. They also provide building blocks for component-resolved diagnostics and safer immunotherapy cocktails that retrain the immune system gently.