AMBP

AMBP, also known as alpha-1-microglobulin/bikunin precursor, plays a vital role in maintaining protein homeostasis and modulating immune responses. It is primarily expressed in the liver and circulates in the bloodstream, where it binds and stabilizes small molecules and peptides. AMBP's dual function involves the scavenging of free radicals and the inhibition of proteolytic enzymes, which is crucial in protecting tissues from oxidative stress and inflammation. Changes in its expression or activity can result from genetic mutations or environmental factors, leading to conditions such as kidney damage or chronic inflammation. Researchers study AMBP to understand its protective roles in various physiological and pathological contexts. Techniques such as gene knockout models and RNA interference are commonly used to investigate its function and regulation. Clinically, evaluating AMBP levels can serve as a biomarker for kidney disease progression and inflammatory states, providing insights into patient health and potential therapeutic targets. By modulating its activity, scientists aim to explore new avenues for treating diseases linked to oxidative stress and protease imbalance.