IDI2

IDI2, or Isopentenyl-Diphosphate Delta Isomerase 2, plays a key role in the isoprenoid biosynthesis pathway. It catalyzes the isomerization of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), essential precursors for cholesterol and other isoprenoids. These molecules are vital for maintaining cell membrane structure, signaling pathways, and protein prenylation. Changes in IDI2 expression or enzyme activity can lead to disruptions in cholesterol homeostasis and affect cellular membrane dynamics, with potential implications for metabolic and degenerative diseases. Research into IDI2 often focuses on its regulatory mechanisms and potential as a therapeutic target. Scientists examine IDI2 activity using genetic and pharmacological methods, such as gene knockdowns or small-molecule inhibitors, to understand its role in cholesterol metabolism and related disorders. Modulating IDI2 can provide insights into the development of lipid-lowering therapies and the management of conditions like hypercholesterolemia. Furthermore, IDI2's function in the broader isoprenoid pathway makes it a candidate for studies on cell growth and proliferation, with implications for cancer research and treatment.