Protenix + SolubleMPNN Refinement | Proteinbase

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Protenix + SolubleMPNN Refinement | Proteinbase

Protenix + SolubleMPNN Refinement

Previous successful binders and hotspots for the target are investigated using Google Scholar Labs. Then, hotspots are manually refined further and input to the Protenix web server with 2VSM PDB Chain A. Retrieved potential binder sequences…

Description

Previous successful binders and hotspots for the target are investigated using Google Scholar Labs. Then, hotspots are manually refined further and input to the Protenix web server with 2VSM PDB Chain A. Retrieved potential binder sequences are then further optimized with SolubleMPNN towards better solubility and expression which were predicted using NetSolP.

Proteins (9)

TableGrid

id: silver-quail-snow

Binder

Other

Protenix + SolubleMPNN Refinement

silver-quail-snow

Nipah Virus Glycoprotein G

0.77

88.77

--

13.5 kDa

124

id: radiant-dove-thorn

Binder

Other

Protenix + SolubleMPNN Refinement

radiant-dove-thorn

Nipah Virus Glycoprotein G

0.80

89.07

--

13.9 kDa

124

id: shy-orca-wave

Binder

Other

Protenix + SolubleMPNN Refinement

shy-orca-wave

Nipah Virus Glycoprotein G

0.78

88.15

--

13.9 kDa

124

id: green-boar-sand

Binder

Other

Protenix + SolubleMPNN Refinement

green-boar-sand

Nipah Virus Glycoprotein G

0.81

89.50

--

13.8 kDa

124

id: young-vole-crystal

Binder

Other

Protenix + SolubleMPNN Refinement

young-vole-crystal

Nipah Virus Glycoprotein G

0.79

89.12

--

13.6 kDa

124

id: calm-raven-willow

Binder

Other

Protenix + SolubleMPNN Refinement

calm-raven-willow

Nipah Virus Glycoprotein G

0.84

87.42

--

13.7 kDa

124

id: quick-quail-pine

Binder

Other

Protenix + SolubleMPNN Refinement

quick-quail-pine

Nipah Virus Glycoprotein G

0.82

90.08

--

13.7 kDa

127

id: dark-deer-willow

Binder

Other

Protenix + SolubleMPNN Refinement

dark-deer-willow

Nipah Virus Glycoprotein G

0.80

87.26

--

13.8 kDa

124

id: silent-crane-birch

Binder

Other

Protenix + SolubleMPNN Refinement

silent-crane-birch

Nipah Virus Glycoprotein G

0.81

87.44

--

13.9 kDa

124

Rows per page

1-9 of 9

About

9proteins generated

0 / 9proteins validated

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

other 100%

Binding Strength

unknown 100%

Expressed

unknown 100%

Classification

mainly Alpha 100%

Architecture

unknown 100%

Collections

MOG-DFM Spotlight

Programmable Biology Group

ProtRL Validation

CRG Ferruz Lab

Adaptyv EGFR Competition Round 1

Adaptyv Bio

EvoDiff Validation

Microsoft Research

Pro-1 validation

Michael Hla

RFdiffusion re-validation

Adaptyv Bio

Adaptyv EGFR Competition Round 2

Adaptyv Bio

DSM Synteract Round 1

Gleghorn Lab X Synthyra

EGFR Round 1 Second Submission

Gitter Lab

Evolved 2024 Bio x ML Team Silica EGFR Nanobodies

BioLM

BindCraft1 publication re-validation

EPFL-LPDI

Mosaic Multispecifics

Escalante Bio

Mosaic Development

Escalante Bio

Nipah Binder Competition: Main Submissions

Adaptyv Bio

BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

Cradle