Description
This collection features proteins designed with Microsoft Research’s EvoDiff, a sequence-first generative model. EvoDiff applied its motif scaffolding strategy to target MDM2, a key regulator of the tumor suppressor p53, generating sequences aimed at blocking the MDM2–p53 interaction.
Proteins (27)
id: bright-kiwi-lava
MDM2
Strong
7.7e-10 M
True
8.6 kDa
76
id: hollow-falcon-reed
MDM2
Strong
2.0e-8 M
True
16.2 kDa
150
id: brisk-boar-cloud
MDM2
Strong
4.4e-8 M
True
12.1 kDa
102
id: dark-cat-cypress
MDM2
Strong
1.4e-8 M
True
10.7 kDa
93
id: soft-bee-vine
MDM2
Medium
6.3e-8 M
True
1.8 kDa
15
id: lunar-panther-wave
MDM2
Medium
5.3e-8 M
True
16.8 kDa
150
id: rough-zebra-ice
MDM2
Strong
4.3e-8 M
True
16.0 kDa
151
id: ivory-bee-fern
MDM2
None
--
True
7.8 kDa
69
id: mellow-fox-lava
MDM2
None
--
True
8.1 kDa
71
id: misty-shark-cloud
MDM2
None
--
True
10.2 kDa
88
id: rapid-shark-dust
MDM2
None
--
True
7.9 kDa
67
id: jade-crane-moss
MDM2
Weak
--
True
7.6 kDa
65
id: quick-raven-ash
MDM2
None
--
True
6.9 kDa
64
id: solid-boar-wave
MDM2
None
--
True
6.3 kDa
62
id: misty-kiwi-thorn
MDM2
None
--
True
10.4 kDa
90
id: strong-bat-rose
MDM2
None
--
True
7.1 kDa
60
id: rapid-heron-pine
MDM2
None
--
True
9.6 kDa
84
id: pale-panda-fern
MDM2
None
--
True
6.8 kDa
59
id: quick-kiwi-marble
MDM2
None
--
True
8.8 kDa
76
id: wild-ox-stone
MDM2
None
--
True
7.9 kDa
75
id: strong-yak-cloud
MDM2
None
--
True
8.5 kDa
74