Synthyra Protein Design Environment

Description

A very large variant population is generated by diffusion pLMs and then scored by several oracles - which are fine-tuned versions of pLMs tailored for specific properties. A genetic algorithm + Monte Carlo scheme is applied to cull poor scoring variants and repopulate with promising variants over many generations. We employ AlphaFold3 look-alikes to calculate interface-based metrics over the most promising candidates, like iPTM, ipSAE, pdockq, pdockq2, and LIS to make our final submission list.

Proteins (20)

TableGrid

LHLogan Hallee

id: hollow-jaguar-bronze

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

83.34

True

20.3 kDa

182

id: strong-vole-snow

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

79.59

False

20.4 kDa

182

id: hollow-quail-frost

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

73.34

True

19.9 kDa

182

id: mellow-raven-ivy

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

85.51

True

20.1 kDa

182

id: rough-ibis-orchid

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

68.36

False

20.2 kDa

182

id: quiet-lion-clay

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

83.24

False

20.2 kDa

182

id: crimson-vole-birch

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

80.22

True

20.0 kDa

182

id: quiet-mole-onyx

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

None

71.07

True

19.9 kDa

182

id: vast-bat-ember

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.65

82.90

20.0 kDa

182

id: gentle-zebra-marble

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.77

72.88

20.0 kDa

182

id: steady-bee-reed

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.75

77.86

20.2 kDa

182

id: green-orca-vine

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.78

76.79

20.0 kDa

182

id: silent-tiger-opal

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.70

67.80

20.4 kDa

182

id: frozen-boar-pearl

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.74

79.55

20.2 kDa

182

id: ivory-bat-iron

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.81

69.73

20.3 kDa

182

id: radiant-kiwi-stone

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.78

71.05

20.3 kDa

182

id: solid-bear-granite

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.77

69.52

20.2 kDa

182

id: green-crane-pine

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.77

69.57

20.2 kDa

182

id: hollow-bear-dust

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.78

71.44

20.0 kDa

182

id: quick-panda-wave

Binder

Other

Synthyra Protein Design Environment

Target

Nipah Virus Glycoprotein G

0.75

67.03

20.0 kDa

182