We trained a two-model LLM framework from scratch to simulate somatic hypermutation, with the goal of predicting plausible, natural-like antibody mutations. We then mutated only the CDRs using LigandMPNN to apply antigen selection pressure to our design. This process was repeated to simulate germinal center antibody maturation.
id: silver-bee-leaf

Multiple (2)
Strong (6)
86.27
True
26.7 kDa
250
id: frozen-yak-granite

Multiple (2)
Strong (6)
True
26.5 kDa
250
id: shy-ibis-stone

Multiple (2)
Strong (6)
True
26.5 kDa
250
id: azure-heron-topaz

Nipah Virus Glycoprotein G
0.49
77.93
--
26.6 kDa
250
id: gentle-bee-ash

Nipah Virus Glycoprotein G
0.65
78.37
--
26.5 kDa
250