RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

RFDiffusion(i/f CDRs, t=30) -> Do Choose top aa: ProteinMPNN p(aa|backbone) x AntiBERTy p(aa|masked sequence)…

Description

RFDiffusion(i/f CDRs, t=30) -> Do Choose top aa: ProteinMPNN p(aa|backbone) x AntiBERTy p(aa|masked sequence) Loop until all aas chosen. AntiFold ranking p(seq|backbone) Curate for sequence & orientation diversity AF3 validation

Proteins (10)

TableGrid

JVJeff Vogt

id: vast-shark-crystal

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.34

73.22

26.5 kDa

249

id: steady-deer-maple

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.03

73.68

26.5 kDa

249

id: quick-bison-dust

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.01

75.61

25.9 kDa

249

id: soft-jaguar-sand

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.22

76.85

25.8 kDa

249

id: strong-vole-willow

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.01

84.89

25.6 kDa

242

id: shy-panda-opal

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.00

77.88

26.2 kDa

248

id: dark-panda-flint

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.00

83.61

25.9 kDa

242

id: crimson-kiwi-ember

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.00

74.95

25.9 kDa

250

id: dark-swan-vine

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.00

81.26

26.2 kDa

248

id: hollow-dove-quartz

Binder

scFv

RFDiffusion + pMPNN + AntiBERTy + AntiFold + AF3

Target

Nipah Virus Glycoprotein G

0.44

77.42

25.9 kDa

250