Pipeline
Description
Mosaic is EscalanteBio's framework for de novo protein binder design. It uses a combination of protein structure prediction and sequence design models to generate high-quality binders. Users can easily modify and add custom loss terms. Mosaic AF2+MPNN is a reproduction of BindCraft in the Mosaic framework with an additional sequence recovery loss.
Proteins (30)
id: golden-cat-lava
Multiple (2)
Medium (2), Strong (2)
True
9.3 kDa
80
id: quick-falcon-stone
Multiple (2)
Weak (2), Strong (2)
True
9.3 kDa
80
id: misty-cat-stone
Multiple (2)
Weak (2), Strong (2)
True
9.5 kDa
80
id: solid-ram-wave
Multiple (2)
Weak (2), Strong (2)
True
9.4 kDa
80
id: brisk-tiger-oak
Multiple (2)
Weak (2), Strong (2)
True
9.2 kDa
80
id: small-goat-ice
Multiple (2)
Weak (2), Strong (2)
True
9.3 kDa
80
id: radiant-bat-ruby
Multiple (2)
Strong (2)
True
9.5 kDa
80
id: bright-otter-reed
Multiple (2)
Weak (2), Strong (2)
True
9.3 kDa
80
id: scarlet-kiwi-thorn
Multiple (2)
Weak (2), Strong (2)
True
9.3 kDa
80
id: bright-panther-frost
Multiple (2)
Strong (2)
True
9.1 kDa
80
id: soft-goat-oak
IL-7Ra
Medium
6.7e-8 M
True
9.9 kDa
80
id: bright-swan-lotus
IL-7Ra
Weak
2.0e-6 M
True
9.7 kDa
80
id: ivory-mole-wave
PD-L1
Weak
2.9e-6 M
True
9.2 kDa
80
id: dark-falcon-maple
IL-7Ra
None
--
True
9.4 kDa
80
id: brisk-goat-snow
IL-7Ra
Strong
1.5e-8 M
True
9.5 kDa
80
id: frozen-panda-maple
IL-7Ra
Strong
3.0e-9 M
True
9.5 kDa
80
id: gentle-raven-marble
IL-7Ra
Medium
4.0e-7 M
True
9.4 kDa
80
id: strong-cobra-iron
IL-7Ra
None
--
True
9.4 kDa
80
id: noble-moth-lava
PD-L1
Medium
2.7e-7 M
True
9.5 kDa
80
id: silent-crane-frost
PD-L1
None
--
True
9.3 kDa
80
id: crimson-tiger-flint
PD-L1
Weak
1.2e-6 M
True
9.2 kDa
80