We designed a de novo binder targeting the stalk region of Nipah virus Glicoprotein G. We used 8gjg (de novo helical peptides trap) as fold-conditioned template to design de novo binder to stalk region of Nipah virus. We then redesign a non-interface regions of binder with ProteinMPNN.
id: golden-swan-willow

Nipah Virus Glycoprotein G
0.66
66.55
--
11.5 kDa
109
id: silver-lynx-flint

Nipah Virus Glycoprotein G
0.70
76.18
--
10.7 kDa
93
id: jade-heron-cypress

Nipah Virus Glycoprotein G
0.76
75.72
--
14.1 kDa
124
id: young-otter-opal

Nipah Virus Glycoprotein G
0.66
77.24
--
19.3 kDa
172
id: deep-bat-jade

Nipah Virus Glycoprotein G
0.67
85.38
--
11.3 kDa
96
id: frozen-panther-cloud

Nipah Virus Glycoprotein G
0.61
83.15
--
18.9 kDa
162
id: quick-toad-ivy

Nipah Virus Glycoprotein G
0.68
85.25
--
18.7 kDa
162