This workflow uses co-TIMED, a modified version of the TIMED model, to design sequences for a protein in the context of its binding partner. The generated sequences are then filtered based on predicted usability (NetSolP), structural predictions (ColabFold), and binding scores (BUDE FF).
id: frozen-goat-lotus

EGFR
Weak
8.3e-6 M
True
5.3 kDa
47
id: silver-crow-birch

EGFR
None
86.81
True
5.2 kDa
47
id: amber-boar-snow

EGFR
None
83.83
True
5.2 kDa
47
id: swift-fox-ice

EGFR
None
84.84
True
5.3 kDa
47
id: young-hawk-ash

EGFR
None
81.17
True
5.5 kDa
47
id: noble-orca-onyx

EGFR
None
84.21
True
5.4 kDa
47
id: noble-falcon-fern

EGFR
None
85.01
True
5.3 kDa
47
id: dark-toad-maple

EGFR
None
85.75
True
5.4 kDa
47
id: gentle-panda-leaf

EGFR
None
85.07
True
5.4 kDa
47
id: rapid-ox-vine

EGFR
None
85.64
True
5.3 kDa
47
id: calm-cat-onyx

EGFR
None
84.73
True
5.4 kDa
47
id: bright-mole-frost

EGFR
None
84.70
True
5.4 kDa
47
id: lunar-otter-lava

EGFR
None
85.96
True
5.3 kDa
47
id: wild-dove-rose

Nipah Virus Glycoprotein G
0.88
76.29
--
9.5 kDa
80
id: wild-falcon-birch

Nipah Virus Glycoprotein G
0.66
84.28
--
13.3 kDa
119
id: rapid-fox-stone

Nipah Virus Glycoprotein G
0.00
84.82
--
13.1 kDa
124