BoltzGen + NovaDesign withipSAE filtering | Proteinbase

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BoltzGen + NovaDesign withipSAE filtering

Selected hot spots with Protean 3D and ElliPro antigenicity prediction and used BoltzGen to generate candidates that were then ranked with NovaDesign/AMBER14. Low ipSAE candidates were filtered out.

Description

Selected hot spots with Protean 3D and ElliPro antigenicity prediction and used BoltzGen to generate candidates that were then ranked with NovaDesign/AMBER14. Low ipSAE candidates were filtered out.

BoltzGen + NovaDesign withipSAE filtering | Proteinbase

Proteins (4)

TableGrid

id: calm-eagle-rose

Binder

Nanobody

BoltzGen + NovaDesign withipSAE filtering

calm-eagle-rose

Nipah Virus Glycoprotein G

0.06

85.93

--

12.7 kDa

118

id: dark-jaguar-ivy

Binder

Nanobody

BoltzGen + NovaDesign withipSAE filtering

dark-jaguar-ivy

Nipah Virus Glycoprotein G

0.01

88.05

--

12.8 kDa

118

id: lunar-boar-moss

Binder

Nanobody

BoltzGen + NovaDesign withipSAE filtering

lunar-boar-moss

Nipah Virus Glycoprotein G

0.51

83.42

--

14.0 kDa

129

id: calm-bear-crystal

Binder

Nanobody

BoltzGen + NovaDesign withipSAE filtering

calm-bear-crystal

Nipah Virus Glycoprotein G

0.82

86.63

--

13.8 kDa

127

Rows per page

1-4 of 4

About

18proteins generated

0 / 18proteins validated

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

nanobody 100%

Binding Strength

unknown 100%

Expressed

unknown 100%

Classification

mainly Beta 100%

Architecture

sandwich 56%

unknown 44%

Collections

Nipah Binder Competition: Main Submissions

Adaptyv Bio

MOG-DFM Spotlight

Programmable Biology Group

ProtRL Validation

CRG Ferruz Lab

Adaptyv EGFR Competition Round 1

Adaptyv Bio

EvoDiff Validation

Microsoft Research

Pro-1 validation

Michael Hla

RFdiffusion re-validation

Adaptyv Bio

Adaptyv EGFR Competition Round 2

Adaptyv Bio

DSM Synteract Round 1

Gleghorn Lab X Synthyra

EGFR Round 1 Second Submission

Gitter Lab

Evolved 2024 Bio x ML Team Silica EGFR Nanobodies

BioLM

BindCraft1 publication re-validation

EPFL-LPDI

Mosaic Multispecifics

Escalante Bio

Mosaic Development

Escalante Bio

Nipah Competition Results

Adaptyv Bio

BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

Cradle