Simple approach while I cook up more interesting designs. Free design with BoltzGen while targeting residues very far into the pocket, specifically V507 and Q559. Reran top 5% of predictions in boltz2 in complex with Nipah virus sequence to calculate ipSAE.
id: silent-mole-stone

Nipah Virus Glycoprotein G
0.78
85.22
--
10.6 kDa
103
id: dark-orca-cypress

Nipah Virus Glycoprotein G
0.58
86.71
--
10.2 kDa
92
id: ivory-lynx-rose

Nipah Virus Glycoprotein G
0.20
83.65
--
10.2 kDa
95
id: radiant-wolf-pearl

Nipah Virus Glycoprotein G
0.00
88.73
--
9.2 kDa
86
id: dark-tiger-cedar

Nipah Virus Glycoprotein G
0.81
85.36
--
13.4 kDa
123
id: bright-jaguar-marble

Nipah Virus Glycoprotein G
0.53
85.34
--
8.5 kDa
80
id: quick-otter-snow

Nipah Virus Glycoprotein G
0.82
84.10
--
10.7 kDa
98
id: golden-panther-iron

Nipah Virus Glycoprotein G
0.71
83.42
--
15.4 kDa
156
id: lunar-yak-clay

Nipah Virus Glycoprotein G
0.74
89.80
--
16.2 kDa
158