RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering | Proteinbase

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JBJulia Bonzanini

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

Generate backbones with RFdiffusion3, sequence design with ProteinMPNN, fold with AlphaFold3 and filter for metrics such as min_pae_interaction, ptm, RMSD

Description

Generate backbones with RFdiffusion3, sequence design with ProteinMPNN, fold with AlphaFold3 and filter for metrics such as min_pae_interaction, ptm, RMSD

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering | Proteinbase

Proteins (8)

TableGrid

JBJulia Bonzanini

id: rapid-vole-onyx

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

rapid-vole-onyx

Nipah Virus Glycoprotein G

0.73

86.79

--

8.4 kDa

73

JBJulia Bonzanini

id: mellow-bat-ash

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

mellow-bat-ash

Nipah Virus Glycoprotein G

0.30

82.12

--

10.0 kDa

86

JBJulia Bonzanini

id: misty-bear-moss

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

misty-bear-moss

Nipah Virus Glycoprotein G

0.00

86.64

--

10.0 kDa

86

JBJulia Bonzanini

id: crimson-dove-iron

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

crimson-dove-iron

Nipah Virus Glycoprotein G

0.00

84.47

--

9.8 kDa

86

JBJulia Bonzanini

id: frozen-heron-jade

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

frozen-heron-jade

Nipah Virus Glycoprotein G

0.00

84.59

--

7.9 kDa

67

JBJulia Bonzanini

id: bright-toad-wave

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

bright-toad-wave

Nipah Virus Glycoprotein G

0.47

84.66

--

7.7 kDa

67

JBJulia Bonzanini

id: small-mole-ember

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

small-mole-ember

Nipah Virus Glycoprotein G

0.00

79.46

--

7.9 kDa

67

JBJulia Bonzanini

id: steady-falcon-leaf

Binder

Miniprotein

RFdiffusion3 + ProteinMPNN + AlphaFold3 filtering

steady-falcon-leaf

Nipah Virus Glycoprotein G

0.60

82.06

--

8.0 kDa

67

Rows per page

1-8 of 8

About

8proteins generated

0 / 8proteins validated

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

miniprotein 100%

Binding Strength

unknown 100%

Expressed

unknown 100%

Classification

mainly Alpha 100%

Architecture

orthogonal Bundle 63%

up Down Bundle 25%

alpha Horseshoe 13%

Collections

Nipah Binder Competition: Main Submissions

Adaptyv Bio

MOG-DFM Spotlight

Programmable Biology Group

ProtRL Validation

CRG Ferruz Lab

Adaptyv EGFR Competition Round 1

Adaptyv Bio

EvoDiff Validation

Microsoft Research

Pro-1 validation

Michael Hla

RFdiffusion re-validation

Adaptyv Bio

Adaptyv EGFR Competition Round 2

Adaptyv Bio

DSM Synteract Round 1

Gleghorn Lab X Synthyra

EGFR Round 1 Second Submission

Gitter Lab

Evolved 2024 Bio x ML Team Silica EGFR Nanobodies

BioLM

BindCraft1 publication re-validation

EPFL-LPDI

Mosaic Multispecifics

Escalante Bio

Mosaic Development

Escalante Bio

Nipah Competition Results

Adaptyv Bio

BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

Cradle