RFDiffusion + ProteinMPNN + fold refinement

The starting point was betasheet heavy designs from previous campaigns which were screened against nipah glycoprotein. The ones with highest ipSAE scores were adapted to the glycoprotein using partial diffusion and finally polished by apply…

Description

Proteins (10)

TableGrid

KBKasper Björnsson

id: rough-bear-leaf

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.72

89.15

12.7 kDa

113

id: brisk-ibis-granite

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.39

90.09

12.5 kDa

113

id: green-mole-onyx

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.08

82.74

12.8 kDa

113

id: rapid-ram-topaz

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.08

88.43

12.6 kDa

113

id: scarlet-bison-crystal

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.06

89.74

12.5 kDa

113

id: azure-ox-cloud

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.31

87.17

12.5 kDa

113

id: calm-bear-sand

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.01

90.95

11.9 kDa

113

id: brisk-bison-sand

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.27

90.07

12.8 kDa

113

id: young-yak-thorn

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.62

85.50

13.8 kDa

127

id: pale-hawk-wave

Binder

Other

RFDiffusion + ProteinMPNN + fold refinement

Target

Nipah Virus Glycoprotein G

0.66

84.25

13.9 kDa

127