RFDiffusion, Boltz, Iterative Biased MPNN

RFDiffusion using 0-4 hotspots around the human ephrinB2 binding site. After screening scaffolds MPNN was used with bias away from AKDE and towards NTSQ to promote soluble residues without too much charge.

Description

Proteins (10)

TableGrid

JFJames Ferguson

id: wild-shark-thorn

Binder

Miniprotein

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.83

79.82

10.0 kDa

id: noble-crane-quartz

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.70

88.69

16.2 kDa

149

id: amber-boar-reed

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.83

89.90

15.7 kDa

143

id: lunar-bat-sand

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.79

88.31

15.3 kDa

143

id: calm-bee-plume

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.83

86.44

15.7 kDa

143

id: quiet-yak-jade

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.80

87.37

15.9 kDa

143

id: golden-eagle-sand

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.82

50.47

14.0 kDa

134

id: quiet-hawk-maple

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.78

87.26

14.9 kDa

134

id: scarlet-swan-quartz

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.82

87.66

10.7 kDa

id: solid-owl-fern

Binder

Other

RFDiffusion, Boltz, Iterative Biased MPNN

Target

Nipah Virus Glycoprotein G

0.79

87.47

15.3 kDa

143