Fully locally implemented on my RTX5060 TI
5 panel streamlit page with enviroment switcher and boltzgen worker script / redis queue Boltzgen implementation for minibinders, VHH, scFv, or scFab scaffold and cdr seed design Seed sequences are handed off to LoRa ESM2 650 M for KD prediction Top candidates from each seed (lineage) are evolved and CDR sequence diversified using an ESM2 650 M WT module These sequences are handed off to biophysical calculations, KD prediction, and other filtering algorithms. Top candidates from the campaign are docked and folded using Colabfold