BoltzGen+ID pipeline | Proteinbase

Proteins
Collections
Targets
Competitions

NINikita Ivanisenko

BoltzGen+ID pipeline

BoltzGen use to generate initial hits, ID pipeline used to refine and select top hots

Description

BoltzGen use to generate initial hits, ID pipeline used to refine and select top hots

BoltzGen+ID pipeline | Proteinbase

Proteins (8)

TableGrid

NINikita Ivanisenko

id: vast-bison-leaf

Binder

Peptide

BoltzGen+ID pipeline

vast-bison-leaf

Nipah Virus Glycoprotein G

None

83.10

True

6.0 kDa

62

NINikita Ivanisenko

id: hollow-bison-onyx

Binder

Other

BoltzGen+ID pipeline

hollow-bison-onyx

Nipah Virus Glycoprotein G

None

88.89

True

10.5 kDa

100

NINikita Ivanisenko

id: solid-crow-moss

Binder

Miniprotein

BoltzGen+ID pipeline

solid-crow-moss

Nipah Virus Glycoprotein G

None

88.76

True

8.7 kDa

82

NINikita Ivanisenko

id: lunar-ant-orchid

Binder

Miniprotein

BoltzGen+ID pipeline

lunar-ant-orchid

Nipah Virus Glycoprotein G

None

88.49

True

8.8 kDa

82

NINikita Ivanisenko

id: golden-owl-fern

Binder

Other

BoltzGen+ID pipeline

golden-owl-fern

Nipah Virus Glycoprotein G

None

87.17

True

11.2 kDa

98

NINikita Ivanisenko

id: silver-crane-lava

Binder

Miniprotein

BoltzGen+ID pipeline

silver-crane-lava

Nipah Virus Glycoprotein G

None

88.74

True

9.4 kDa

82

NINikita Ivanisenko

id: strong-ant-wave

Binder

Miniprotein

BoltzGen+ID pipeline

strong-ant-wave

Nipah Virus Glycoprotein G

None

88.67

True

9.3 kDa

82

NINikita Ivanisenko

id: deep-panda-ash

Binder

Peptide

BoltzGen+ID pipeline

deep-panda-ash

Nipah Virus Glycoprotein G

None

89.10

True

8.1 kDa

74

Rows per page

1-8 of 8

About

38proteins generated

8 / 38proteins validated

100%expression rate

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

miniprotein 55%

other 21%

peptide 18%

nanobody 5%

Binding Strength

unknown 79%

none 21%

Expressed

unknown 79%

true 21%

De Novo

unknown 79%

yes 18%

no 3%

Classification

mainly Alpha 53%

mainly Beta 29%

alpha Beta 18%

Architecture

unknown 76%

orthogonal Bundle 5%

roll 5%

sandwich 5%

2 Layer Sandwich 3%

7 Propeller 3%

beta Barrel 3%

Collections

Nipah Binder Competition: Main Submissions

Adaptyv Bio

MOG-DFM Spotlight

Programmable Biology Group

ProtRL Validation

CRG Ferruz Lab

Adaptyv EGFR Competition Round 1

Adaptyv Bio

EvoDiff Validation

Microsoft Research

Pro-1 validation

Michael Hla

RFdiffusion re-validation

Adaptyv Bio

Adaptyv EGFR Competition Round 2

Adaptyv Bio

DSM Synteract Round 1

Gleghorn Lab X Synthyra

EGFR Round 1 Second Submission

Gitter Lab

Evolved 2024 Bio x ML Team Silica EGFR Nanobodies

BioLM

BindCraft1 publication re-validation

EPFL-LPDI

Mosaic Multispecifics

Escalante Bio

Mosaic Development

Escalante Bio

Nipah Competition Results

Adaptyv Bio

BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

Cradle