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BindCraft + Molecular Dynamics Scoring | Proteinbase

RRita-Ann-Roessner

BindCraft + Molecular Dynamics Scoring

Binders were designed using BindCraft with the full-length experimental structure (PDB ID: 2VSM) as the target input. Design generation employed the default_4stage_multimer_flexible_hardtarget.json advanced settings. Selected designs were t…

Description

Binders were designed using BindCraft with the full-length experimental structure (PDB ID: 2VSM) as the target input. Design generation employed the default_4stage_multimer_flexible_hardtarget.json advanced settings.

Selected designs were then subjected to molecular dynamics simulations. Finally, designs were filtered based on MD-computed binding free energies to identify the most promising candidates.

About

10proteins generated

0 / 10proteins validated

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

other 100%

Binding Strength

unknown 100%

Expressed

unknown 100%

Classification

mainly Alpha 100%

Architecture

unknown 100%

Collections

MOG-DFM Spotlight

Programmable Biology Group

ProtRL Validation

CRG Ferruz Lab

Adaptyv EGFR Competition Round 1

Adaptyv Bio

EvoDiff Validation

Microsoft Research

Pro-1 validation

Michael Hla

RFdiffusion re-validation

Adaptyv Bio

Adaptyv EGFR Competition Round 2

Adaptyv Bio

DSM Synteract Round 1

Gleghorn Lab X Synthyra

EGFR Round 1 Second Submission

Gitter Lab

Evolved 2024 Bio x ML Team Silica EGFR Nanobodies

BioLM

BindCraft1 publication re-validation

EPFL-LPDI

Mosaic Multispecifics

Escalante Bio

Mosaic Development

Escalante Bio

Nipah Binder Competition: Main Submissions

Adaptyv Bio

BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

Cradle

Proteins (10)

TableGrid

RRita-Ann-Roessner

id: young-vole-topaz

Binder

Other

BindCraft + Molecular Dynamics Scoring

young-vole-topaz

Nipah Virus Glycoprotein G

0.76

83.42

--

17.3 kDa

146

RRita-Ann-Roessner

id: soft-cobra-cypress

Binder

Other

BindCraft + Molecular Dynamics Scoring

soft-cobra-cypress

Nipah Virus Glycoprotein G

0.72

78.43

--

17.4 kDa

146

RRita-Ann-Roessner

id: misty-panda-snow

Binder

Other

BindCraft + Molecular Dynamics Scoring

misty-panda-snow

Nipah Virus Glycoprotein G

0.60

82.64

--

22.7 kDa

187

RRita-Ann-Roessner

id: hollow-vole-orchid

Binder

Other

BindCraft + Molecular Dynamics Scoring

hollow-vole-orchid

Nipah Virus Glycoprotein G

0.40

83.56

--

22.4 kDa

187

RRita-Ann-Roessner

id: gentle-lion-cedar

Binder

Other

BindCraft + Molecular Dynamics Scoring

gentle-lion-cedar

Nipah Virus Glycoprotein G

0.59

85.18

--

13.1 kDa

108

RRita-Ann-Roessner

id: rapid-ibis-granite

Binder

Other

BindCraft + Molecular Dynamics Scoring

rapid-ibis-granite

Nipah Virus Glycoprotein G

0.62

80.89

--

19.8 kDa

165

RRita-Ann-Roessner

id: strong-panda-orchid

Binder

Other

BindCraft + Molecular Dynamics Scoring

strong-panda-orchid

Nipah Virus Glycoprotein G

0.57

88.43

--

21.7 kDa

185

RRita-Ann-Roessner

id: silent-kiwi-sand

Binder

Other

BindCraft + Molecular Dynamics Scoring

silent-kiwi-sand

Nipah Virus Glycoprotein G

0.59

78.53

--

19.4 kDa

161

RRita-Ann-Roessner

id: noble-otter-moss

Binder

Other

BindCraft + Molecular Dynamics Scoring

noble-otter-moss

Nipah Virus Glycoprotein G

0.26

84.65

--

23.0 kDa

196

RRita-Ann-Roessner

id: scarlet-tiger-ember

Binder

Other

BindCraft + Molecular Dynamics Scoring

scarlet-tiger-ember

Nipah Virus Glycoprotein G

0.00

83.29

--

23.5 kDa

195

Rows per page

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