AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY | Proteinbase

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AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY | Proteinbase

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

1. Generate two batches of candidate antibodies using in-house pretrained pLMs trained on >1 million human antibody sequences. 2. Produce target-agnostic sequences, then perform focused redesign of CDR3 regions with the same in-house pLMs t…

Description

Generate two batches of candidate antibodies using in-house pretrained pLMs trained on >1 million human antibody sequences.
Produce target-agnostic sequences, then perform focused redesign of CDR3 regions with the same in-house pLMs to increase diversity and potential specificity.
Predict antibody structures with tFold-Ab for high-accuracy immunoglobulin modeling.
Model the Nipah viral target protein using AlphaFold-3.
Assemble antibody–target complexes and pass them into RFAntibody for structure-aware optimization against the target.
Evaluate and rank designs using key metrics: ipAE, mean pAE, and ΔΔG.
Select top-performing antibodies based on combined structural and energetic criteria.
Maintain a minimal toolchain throughout to preserve pipeline simplicity, efficiency, and robustness.

Proteins (10)

TableGrid

id: radiant-bee-maple

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

radiant-bee-maple

Nipah Virus Glycoprotein G

0.38

80.73

--

14.0 kDa

131

id: rapid-orca-crystal

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

rapid-orca-crystal

Nipah Virus Glycoprotein G

0.12

87.65

--

11.2 kDa

110

id: ivory-falcon-lotus

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

ivory-falcon-lotus

Nipah Virus Glycoprotein G

0.00

79.78

--

13.7 kDa

131

id: frozen-deer-jade

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

frozen-deer-jade

Nipah Virus Glycoprotein G

0.47

88.86

--

11.4 kDa

110

id: bright-ibis-plume

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

bright-ibis-plume

Nipah Virus Glycoprotein G

0.00

86.60

--

14.1 kDa

130

id: gentle-vole-cypress

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

gentle-vole-cypress

Nipah Virus Glycoprotein G

0.00

89.33

--

11.5 kDa

110

id: dark-eagle-quartz

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

dark-eagle-quartz

Nipah Virus Glycoprotein G

0.00

75.83

--

11.0 kDa

106

id: bright-bear-stone

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

bright-bear-stone

Nipah Virus Glycoprotein G

0.03

78.88

--

14.0 kDa

131

id: quick-yak-ruby

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

quick-yak-ruby

Nipah Virus Glycoprotein G

0.65

79.11

--

13.8 kDa

131

id: deep-ibis-frost

Binder

Nanobody

AbSynth(pLM)+tFold-Ab+AlphaFold3+RFAntibody+PRODIGY

deep-ibis-frost

Nipah Virus Glycoprotein G

0.00

87.47

--

11.3 kDa

110

Rows per page

1-10 of 10

About

10proteins generated

0 / 10proteins validated

Targets

Nipah Virus Glycoprotein G

0 binders•-- avg KD

Design Class

nanobody 100%

Binding Strength

unknown 100%

Expressed

unknown 100%

Classification

mainly Beta 100%

Architecture

unknown 100%

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EGFR Round 1 Second Submission

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Nipah Binder Competition: Main Submissions

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BoltzGen Release

Massachusetts Institute of Technology

Cradle EGFR Competition Follow Up

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