Miniprotein violet-lynx-reed

Max Beining / violet-lynx-reed

Type

Miniprotein

Binding

Nipah Virus Glycoprotein G

Strong

Human Serum Albumin

None

Expressed

Yes

Ref

N1011

Collections

MSubmission 6

ANipah Binder Competition: Main Submissions

ANipah Competition Results

Awards

#69Nipah Binder Competition

Sequence (82 AA)

EAELIAEYEARRAAELAALQAEIDALKALIKELGEAKYADLISTLDDEFAAAKEDPRLRIYLRGKIKLLTKKLKAEKAAKAA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

6.63pH

Molecular Weight

9041.41Da

Download CIF

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Binding

Yes

Binding Strength

Strong, Medium

6.1e-8M

Kon

1.1e+4M-1s-1

Koff

5.7e-4s-1

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Kinetic Curves (SPR)

Fit Model

Concentration

0.10 nM

0.30 nM

1.00 nM

3.20 nM

10.0 nM

31.6 nM

100 nM

316 nM

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Design Method

This protein was designed using MBRFdiffusion (full,partial) + AlphaFold/Boltz pred + Rosetta filtering