Submission 6 | Proteinbase

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Submission 6 | Proteinbase

Max Beining/Submission 6

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Submitted toNipah Binder Competition

About

6proteins designed

6proteins validated

6binders

100%expression rate

0.85Avg ipSAE

Design Methods

MBRFdiffusion (full,partial) + AlphaFold/Boltz pred + Rosetta filtering2 MBRFdiffusion (full,partial) + PMPNN + AlphaFold/Boltz pred + Rosetta filtering2 MBRFdiffusion (full/partial) + PMPNN + AF/boltz valid + Rosetta filtering2

Targets

Nipah Virus Glycoprotein G

6 binders•6.8e-8 avg KD

Human Serum Albumin

0 binders•-- avg KD

Design Class

miniprotein 100%

Binding Strength

none 40%

medium 33%

strong 27%

Expressed

true 100%

De Novo

yes 100%

Classification

mainly Alpha 100%

Architecture

up Down Bundle 67%

unknown 33%

Proteins (6)

TableGrid

id: bright-moth-stone

Binder

Miniprotein

RFdiffusion (full,partial) + AlphaFold/Boltz pred + Rosetta filtering

bright-moth-stone

Multiple (2)

Strong (6)

True

8.9 kDa

82

id: scarlet-boar-quartz

Binder

Miniprotein

RFdiffusion (full,partial) + PMPNN + AlphaFold/Boltz pred + Rosetta filtering

scarlet-boar-quartz

Multiple (2)

Medium (2), Strong (4)

True

9.4 kDa

82

id: pale-cat-plume

Binder

Miniprotein

RFdiffusion (full/partial) + PMPNN + AF/boltz valid + Rosetta filtering

pale-cat-plume

Multiple (2)

Medium (2), Strong (4)

True

9.4 kDa

82

id: violet-lynx-reed

Binder

Miniprotein

RFdiffusion (full,partial) + AlphaFold/Boltz pred + Rosetta filtering

violet-lynx-reed

Multiple (2)

Medium (4), Strong (2)

True

9.0 kDa

82

id: frozen-raven-maple

Binder

Miniprotein

RFdiffusion (full,partial) + PMPNN + AlphaFold/Boltz pred + Rosetta filtering

frozen-raven-maple

Multiple (2)

Medium (6)

True

9.2 kDa

82

id: golden-bison-reed

Binder

Miniprotein

RFdiffusion (full/partial) + PMPNN + AF/boltz valid + Rosetta filtering

golden-bison-reed

Multiple (2)

Medium (6)

True

9.1 kDa

82

Rows per page

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