Miniprotein shy-vole-vine

Google DeepMind / shy-vole-vine

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0877

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (133 AA)

SEVEELIRQAILALALGDREAAAAYLRKLAELEKERRDFYLHVADVLLKTTDENVLLAAIAILISYILEKFPKEKAEEFLMELAEELLASDAPLEVKAAFLSIAASLLELYGGNPEVIARLRAEAARLRAEAA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.71pH

Molecular Weight

14.7kDa

Download CIF

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Binding

Yes

Binding Strength

Medium, Weak

K_D

1.1×10⁻⁶M

k_on

8.5×10³M^-1s^-1

k_off

9.0×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN