Miniprotein noble-ox-cedar

simsjn / noble-ox-cedar

Type

Miniprotein

Binding

Nipah Virus Glycoprotein G

Strong

Human Serum Albumin

None

Expressed

Yes

Ref

2g9sol1

Collections

SSubmission 1

ANipah Binder Competition: Main Submissions

ANipah Competition Results

Awards

#10Nipah Binder Competition

Sequence (78 AA)

SGLDEYAELLAEGWKRKVDAGQDIKFTIKFQEFSPNLWGLEPEEIYEAAMKAANSIEGAEVTVEENGDYKTITIKKAP

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.48pH

Molecular Weight

8723.65Da

Download CIF

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Binding

Yes

Binding Strength

Strong

2.4e-9M

Kon

1.2e+5M-1s-1

Koff

2.4e-4s-1

Neutralization

Full

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Kinetic Curves (SPR)

Fit Model

Concentration

0.10 nM

0.30 nM

1.00 nM

3.20 nM

10.0 nM

31.6 nM

100 nM

316 nM

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Design Method

This protein was designed using BLRFdiffusion

RFD --> MPNN --> AF2