Miniprotein young-cobra-dust

Google DeepMind / young-cobra-dust

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_1064

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (127 AA)

SDEEVIDLLKKLEDALKAGDLDGALAALREAVEKVLKREKLSPEAKSLLRQALDALEQGDFNKADELLYKASLLAAEEGGSLTTHVVIAAALILGVALRSKDPHLIRACAMEIEKLIKLLEEYKKKK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.50pH

Molecular Weight

13.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

8.1×10⁻⁷M

k_on

3.7×10³M^-1s^-1

k_off

2.9×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN