Miniprotein wild-otter-dust

Google DeepMind / wild-otter-dust

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0813

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (94 AA)

LLERRARLINGLHEALKVVLEALKGKEEELEKLEGPFADAVYALVKAGLTGTEEALAEAEAAVRAFFEEAIKTLKELGKDEAVEKLKELWAKYF

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.01pH

Molecular Weight

10.5kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

1.2×10⁻⁹M

k_on

1.6×10⁵M^-1s^-1

k_off

1.9×10⁻⁴s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN