Miniprotein wild-jaguar-maple

Google DeepMind / wild-jaguar-maple

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0834

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (132 AA)

GFKEASPEEVLDDFVEGLYKLAETLPEEYGKKLKELAEKLREAALARDFEALVELGVETVKLLVEAKAPPRSIAATVAALVAVLAALEAPLESLERFREEVEKIAEEVESENQRSALRAALVVVDETIEALR

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.52pH

Molecular Weight

14.5kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

1.1×10⁻⁸M

k_on

2.4×10⁶M^-1s^-1

k_off

2.5×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN