Miniprotein violet-lion-reed

Google DeepMind / violet-lion-reed

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1108

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (136 AA)

SIEELLQKAKELMKSTDGRERAEAVRTLQEIAEKAEEASQEQITEGAELALEAAEQEATDPNGSLGLALEALKAALGLVPMLPTEEALALLERMREVLEKLRERAKTIPDENARKAVLDEVDELLERLDHLRAALA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.55pH

Molecular Weight

15.0kDa

Download CIF

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Binding

Yes

Binding Strength

Medium, Strong

K_D

5.4×10⁻⁸M

k_on

5.2×10⁵M^-1s^-1

k_off

2.6×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN