Miniprotein violet-heron-ivy | Proteinbase

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Miniprotein violet-heron-ivy | Proteinbase

GD

Google DeepMind / violet-heron-ivy

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1141

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (65 AA)

SAVEKAIENAKKGLENAKKDGASELSIRGLKSAINLLEEYKNGVVPEELKPDAEDLIKYFSSIKD

Sequence (65 AA)

SAVEKAIENAKKGLENAKKDGASELSIRGLKSAINLLEEYKNGVVPEELKPDAEDLIKYFSSIKD

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.14pH

Molecular Weight

7.1kDa

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Binding

Yes

Binding Strength

Strong

K_D

1.9×10⁻⁸M

k_on

4.5×10⁵M^-1s^-1

k_off

7.5×10⁻³s^-1

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN

Proteins
violet-heron-ivy

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM