Miniprotein vast-owl-opal

Google DeepMind / vast-owl-opal

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Weak

Expressed

Yes

Ref

PDW_1123

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

VSEETNAAITTLSIGADLIANGEESEEVAAALKALSDEQIRAALEAMGEKARELEAAGQEEQARGLMNNILLGAGAYKAVRAGKRLADVDPVDALNEVFKTAGPVTSVDEAVAAALAYLA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.31pH

Molecular Weight

12.3kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Weak

K_D

1.1×10⁻⁶M

k_on

2.4×10⁴M^-1s^-1

k_off

2.7×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN