Miniprotein vast-crane-cloud

Google DeepMind / vast-crane-cloud

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1148

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (78 AA)

SKIEEIKKLIEEALSATSQEVRLAYAKKVAEIISKLDREEIDEVVKKLGDKIRLLDEECAEIVYGALLEKGKKIEEEE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.83pH

Molecular Weight

8.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

4.9×10⁻⁷M

k_on

1.2×10⁵M^-1s^-1

k_off

5.7×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN