Miniprotein swift-gecko-stone

Google DeepMind / swift-gecko-stone

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0867

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (128 AA)

ELTRRLLLEALELLAKAAELLKEAAKDPSLQAACEELRERLERLRRDLAAGRISDEEAANEIRYLGAAIIDFAKALLELGDVEAARKVLELLREAADKLIAGGGDAAIAGRDLAALIDHLEELIDAKE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.71pH

Molecular Weight

13.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

1.2×10⁻⁷M

k_on

1.1×10⁶M^-1s^-1

k_off

1.3×10⁻¹s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN