Miniprotein solid-heron-cedar

Google DeepMind / solid-heron-cedar

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0857

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (129 AA)

QEALREAAEATQRELTALIDEIVKESKDFSEKDKEALSEAITLATNAMHIVLRRLLGSDEEIPSSGDERVDAWLEEMRAAPLEELPALLRRAAEELIKEYKLSEKAKALLDRLVARAEALMARLLAVAR

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.84pH

Molecular Weight

14.4kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

4.7×10⁻⁸M

k_on

1.4×10⁶M^-1s^-1

k_off

6.7×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN