Miniprotein small-bee-dust

Google DeepMind / small-bee-dust

Type

Miniprotein

Binding

PD-L1

Strong

Expressed

Yes

Ref

PDW_1538

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (107 AA)

TPLERALSDLKVLLEEALKGRNKSDILSLLRFLAILVKEAAERGDEAVAQRAVDLFHEALDKAKPILSEKDLQKLIGVFQKLRDAAKTDLAKELLDQMIEYIEEIIK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.25pH

Molecular Weight

12.1kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

1.1×10⁻⁸M

k_on

2.1×10⁵M^-1s^-1

k_off

2.1×10⁻³s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN