Miniprotein silent-seal-stone

Google DeepMind / silent-seal-stone

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1167

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (101 AA)

VVTATVSLSADTFKPGETVTATGTVWGSGFPAGSRAFVVVKAFDEDGNEIASGQGTGAVPGTVTATVTVPANASKVRAFAGYGVLGTGNGYVLASAEAAVV

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.72pH

Molecular Weight

9.8kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

4.5×10⁻⁸M

k_on

9.4×10⁴M^-1s^-1

k_off

4.2×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN