Miniprotein silent-bison-pine

Google DeepMind / silent-bison-pine

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Weak

Expressed

Yes

Ref

PDW_1107

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (136 AA)

SIDELLAEAKALLKSTDGAELAKAVDTLLKIAEKAEEASLEQIREAAELALEAARRLAEDPNGSLGLALEALKAALGLVPMLPREEALALLERMREVLERLRERAKTIPDENARKAVLEEVDDLEERIDHLEANLA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.58pH

Molecular Weight

14.9kDa

Download CIF

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Binding

Yes

Binding Strength

Weak

K_D

1.1×10⁻⁶M

k_on

2.0×10⁴M^-1s^-1

k_off

2.3×10⁻²s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN