Miniprotein silent-ant-topaz

Google DeepMind / silent-ant-topaz

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1117

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (87 AA)

SLSVEEVAKAIKKAKEAAGRTGPVTLGDLIGLALGNDALGAWFRERTGLDPEEALEAIQAGDLAAIDEAEAAAAPVLAELEAALKKL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.45pH

Molecular Weight

8.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

2.0×10⁻⁸M

k_on

6.1×10⁵M^-1s^-1

k_off

9.9×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN