Miniprotein scarlet-lynx-quartz

Google DeepMind / scarlet-lynx-quartz

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0892

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (125 AA)

AVNLLELADLARKLAEELKDVDPALAAELLEAADALRRLAAEYGDPDGNLTEEALRKLTPEELAALSAAGLVLLVATVKLAELKGLPVDWDRAYEIARRLSSADPAVLLEGLRALQEEARRVLAE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.54pH

Molecular Weight

13.4kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

6.9×10⁻⁹M

k_on

2.1×10⁶M^-1s^-1

k_off

1.4×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN