Miniprotein rapid-ibis-wave

Google DeepMind / rapid-ibis-wave

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0854

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (129 AA)

REALRQAAEDTQRRLTELIEKIVKESKSLSDKDKEALSEAIAAATNAAHIVLRRLLGSDEEIPSTGDARVDAYLAEMEAAPLEELPALLERFREELIKEYKLSEKAEALMDELVAETIRLMEELLALAR

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.67pH

Molecular Weight

14.5kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

2.6×10⁻⁷M

k_on

8.3×10⁵M^-1s^-1

k_off

2.2×10⁻¹s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN