Miniprotein rapid-cobra-flint | Proteinbase

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Design Methods
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Miniprotein rapid-cobra-flint | Proteinbase

GD

Google DeepMind / rapid-cobra-flint

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1145

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (65 AA)

SAVEKAIANAKAGLENAKKDGASEESIRGLESAINLLEEYKAGVVPESLKDDAEYLVEYFTNVKD

Sequence (65 AA)

SAVEKAIANAKAGLENAKKDGASEESIRGLESAINLLEEYKAGVVPESLKDDAEYLVEYFTNVKD

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.54pH

Molecular Weight

7.0kDa

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Binding

Yes

Binding Strength

Medium, Strong

K_D

5.0×10⁻⁸M

k_on

4.1×10⁵M^-1s^-1

k_off

1.8×10⁻²s^-1

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN

Proteins
rapid-cobra-flint

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM