Miniprotein radiant-toad-bronze

Google DeepMind / radiant-toad-bronze

Type

Miniprotein

Binding

PD-L1

Weak

Expressed

Yes

Ref

PDW_1552

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (81 AA)

KEEEEDLLDLLAAQALLALQHKDEQQAIALMRQMYKLAAESTDRRLKKRAAGLLEALAAIAERLGLDRVAAEARRLAAELR

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.86pH

Molecular Weight

9.0kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Weak

K_D

1.2×10⁻⁶M

k_on

5.8×10³M^-1s^-1

k_off

6.6×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN