Miniprotein radiant-gecko-lava

Google DeepMind / radiant-gecko-lava

Type

Miniprotein

Binding

PD-L1

Weak

Expressed

Yes

Ref

PDW_1376

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (92 AA)

SLEDELRAILHQIGTAKDREEIIKLLKELEKLLEKADLETAKFFAIAAILIASNKLQLPSEEVNEYIIKILNSKNKKELLKILKEFIDKLEK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.90pH

Molecular Weight

10.6kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Weak

K_D

1.4×10⁻⁶M

k_on

3.1×10⁴M^-1s^-1

k_off

4.3×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN