Miniprotein quiet-moth-ash

Google DeepMind / quiet-moth-ash

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1273

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (101 AA)

LCTATLTVDRKTAHPGDTVTASATGTGACTVSGAKVFVVMLAFDASGNQVASASGSAGCGETATAELTVPSGASKVLCLAGVGYPEANTGYIHDWGEITVL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.74pH

Molecular Weight

9.9kDa

Download CIF

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Binding

Yes

Binding Strength

Medium, Weak

K_D

9.7×10⁻⁷M

k_on

7.7×10³M^-1s^-1

k_off

7.4×10⁻³s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN