Miniprotein quiet-hawk-granite

Google DeepMind / quiet-hawk-granite

Type

Miniprotein

Binding

PD-L1

Strong

Expressed

Yes

Ref

PDW_1354

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

SAEEKVLANLENMKKKALEAKTEEEKLVYAKALLAVAISYAIRGDEALAERAAELAVEVINSLSKEQQKRAMDFAINIIKNVTDPEDREVCIELLIRIAERLDEEVREEALKKIEELKKE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.90pH

Molecular Weight

13.6kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

1.0×10⁻⁹M

k_on

5.4×10⁴M^-1s^-1

k_off

5.5×10⁻⁵s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN