Miniprotein quiet-fox-iron

Google DeepMind / quiet-fox-iron

Type

Miniprotein

Binding

PD-L1

Strong

Expressed

Yes

Ref

PDW_1534

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

TAEEKVLENLEAMKQKALQAKSEEEKLVYAKALLSVAFAYAIRGDEKLAEKAAELAVEVINELSKAEQERAMGFALNVIQNVTDPEAKQKCIELARWIAERLDEEVQAKALKEIAELEEE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.68pH

Molecular Weight

13.4kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

1.1×10⁻⁹M

k_on

1.3×10⁵M^-1s^-1

k_off

1.2×10⁻⁴s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN